|Application ||WB, FC|
|Isotype||Human IgG1, lambda|
|Calculated MW||76075 Da|
|Other Names||beta-gal; Acid beta galactosidase; Beta galactosidase 1; β-galactosidase; β-gal; EBP; ELNR1; Galactosidase beta 1; GLB1; MPS4B|
|Formulation||200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300|
|Reconstitution & Storage||-20 °C|
|Precautions||Anti-Beta-galactosidase, Human IgG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.|
|Cellular Location||Isoform 1: Lysosome|
|Tissue Location||Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208).|
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Provided below are standard protocols that you may find useful for product applications.
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers
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