|Application ||WB, IHC-F, IF, E, IP, RIA|
|Isotype||Human IgG1, kappa|
|Other Names||CDW52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5|
|Formulation||200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300|
|Reconstitution & Storage||-20 °C|
|Precautions||Anti-CD52 (Campath-1H), Human IgG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in carrying and orienting carbohydrate, as well as having a more specific role.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. EMBL; X62466; CAA44323.1; -; mRNA EMBL; X67699; CAA47929.1; -; mRNA EMBL; AL451139; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC000644; AAH00644.1; -; mRNA CCDS; CCDS30647.1; - PIR; S18766; S18766 RefSeq; NP_001794.2; NM_001803.2 UniGene; Hs.276770; - ProteinModelPortal; P31358; - BioGrid; 107473; 2 STRING; 9606.ENSP00000363330; - ChEMBL; CHEMBL1912; - DrugBank; DB00087; Alemtuzumab BioMuta; CD52; - PaxDb; P31358; - PRIDE; P31358; - ProteomicsDB; 54785; - DNASU; 1043; - Ensembl; ENST00000374213; ENSP00000363330; ENSG00000169442 GeneID; 1043; - KEGG; hsa:1043; - CTD; 1043; - DisGeNET; 1043; - EuPathDB; HostDB:ENSG00000169442.8; - GeneCards; CD52; - HGNC; HGNC:1804; CD52 MIM; 114280; gene neXtProt; NX_P31358; - OpenTargets; ENSG00000169442; - PharmGKB; PA26350; - eggNOG; ENOG410KC6Z; Eukaryota eggNOG; ENOG4110P9R; LUCA GeneTree; ENSGT00860000134004; - HOGENOM; HOG000111488; - HOVERGEN; HBG001036; - InParanoid; P31358; - KO; K06488; - OMA; LVMIQIQ; - PhylomeDB; P31358; - TreeFam; TF338573; - Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins SIGNOR; P31358; - ChiTaRS; CD52; human GeneWiki; CD52; - GenomeRNAi; 1043; - PRO; PR:P31358; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000169442; - CleanEx; HS_CD52; - ExpressionAtlas; P31358; baseline and differential Genevisible; P31358; HS GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0031226; C:intrinsic component of plasma membrane; TAS:UniProtKB GO; GO:0016020; C:membrane; TAS:ProtInc GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB GO; GO:0045730; P:respiratory burst; NAS:UniProtKB InterPro; IPR026643; CAMPATH-1 PANTHER; PTHR15029; PTHR15029; 1 Pfam; PF15116; CD52; 1 1: Evidence at protein level; Cell membrane; Complete proteome; Direct protein sequencing; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Polymorphism; Reference proteome; Signal SIGNAL 1 24 PEPTIDE 25 36 CAMPATH-1 antigen /FTId=PRO_0000020904 PROPEP 37 61 Removed in mature form. /FTId=PRO_0000020905 LIPID 36 36 GPI-anchor amidated serine CARBOHYD 27 27 N-linked (GlcNAc...) asparagine CARBOHYD 40 40 N-linked (GlcNAc...) asparagine VARIANT 40 41 NI -> SM /FTId=VAR_005130 VARIANT 40 40 N -> S (in dbSNP:rs1071849) /FTId=VAR_050775 VARIANT 41 41 I -> M (in dbSNP:rs17645) /FTId=VAR_014838 SEQUENCE 61 AA; 6614 MW; 4AE2A056682BEEA6 CRC64; MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF S|
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Provided below are standard protocols that you may find useful for product applications.
Human CD52 antigen, also known as CAMPATH-1. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable.
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