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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Alpha 2 HS Glycoprotein Antibody   

Alpha 2 HS Glycoprotein Antibody

Rabbit Polyclonal Antibody

     
  • WB - Alpha 2 HS Glycoprotein Antibody ABV11805-100
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P02765
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39325 Da
Additional Information
Gene ID 197
Positive Control WB: h serum, h alpha 2 HS Glycoprotein
Application & Usage WB: 1-4 µg
Alias Symbol AHSG
Other Names Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A
Appearance Colorless liquid
Formulation In PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAlpha 2 HS Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHSG
Synonyms FETUA
Function Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Cellular Location Secreted.
Tissue Location Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins
Research Areas
Citations (0)

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Background

Alpha 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. It functions as a broad-spectrum protease-binding protein. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells.

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$ 265.00
$ 89.00
Cat# ABV11805-100
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