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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Prothrombin Antibody   

Prothrombin Antibody

Rabbit Polyclonal Antibody

     
  • WB - Prothrombin Antibody ABV11808-100
    Western blot with human Prothrombin antibody in: Lane1: h Prothrombin,10ng; Lane2: h Prothrombin, 2ng; Lane3: h serum, 1 µg
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession  , P00734
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Additional Information
Positive Control WB: h Prothrombin, h serum
Application & Usage WB: 1-4 µg
Alias Symbol F2
Other Names Coagulation factor II
Appearance Colorless liquid
Formulation In PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsProthrombin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
Citations (0)

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Background

Prothrombin is a vitamin K-dependent plasma protein which is synthesized in the liver. Prior to secretion into plasma, prothrombin undergoes post-translational modification by a vitamin K-dependent carboxylase which converts ten specific glutamic acid residues to γ-carboxyglutamic acid (gla). Conversion to thrombin is a key step in the blood coagulation pathway and catalyzes the coagulation of fibrinogen. Clinically, cases of selective deficiency are rare, although, in cases of liver cirrhosis, prothrombin is decreased. During activation, prothrombin is cleaved at Arg271-Thr272 and at Arg320-Ser321 to a "pro" fragment (fragment 1.2) and thrombin, the latter of which is composed of two chains covalently linked by a disulfide bond. There is an additional thrombin feed-back cleavage at Arg284-Thr285 resulting in an additional 13 amino acids being removed from the mature thrombin “A” chain.

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$ 265.00
$ 89.00
Cat# ABV11808-100
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