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Anti-ACTA2 Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P62736 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42009 Da |
| Gene ID | 59 |
|---|---|
| Positive Control | WB: heart tissue lysate, IHC: kidney and heart tissue sections |
| Application & Usage | IHC: 1:1000 -1:2500 dilution; WB: 1:1000 - 1:2000 dilution |
| Alias Symbol | ACTA2 |
| Other Names | alpha smooth muscle Actin Alpha-actin-2, Cell growth-inhibiting gene 46 protein |
| Appearance | Colorless liquid |
| Formulation | In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-ACTA2 Rabbit Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACTA2 |
|---|---|
| Synonyms | ACTSA, ACTVS |
| Function | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Cellular Location | Cytoplasm, cytoskeleton. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Actins are highly conserved proteins expressed in all eucaryotic cells. Actin filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue-specific manner, alpha and beta cytoplasmic actins are expressed in a wide variety of cells; whereas, expression of alpha skeletal, alpha cardiac, alpha vascular, and gamma enteric actins are more restricted to specialized muscle cell type. Smooth muscle alpha actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Furthermore, expression of smooth muscle alpha actin is regulated by hormones, cell proliferation, and altered by pathological conditions including oncogenic transformation and atherosclerosis.
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