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Anti-Desmin Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibody

     
  • IHC - Anti-Desmin Rabbit Monoclonal Antibody ABV11825-50
    Immunohistochemical staining of formalin fixed and paraffin embedded human heart tissue sections using anti-Desmin monoclonal antibody at a1:4000 dilution.
    detail
  • WB - Anti-Desmin Rabbit Monoclonal Antibody ABV11825-50
    Western blot of M.heart tissue lysates using anti-Desmin monoclonal antibody at 1:1000 dilution, showed a band of Desmin (~54kDa) expressed in M.heart.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P17661
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Isotype Rabbit IgG
Calculated MW 53536 Da
Additional Information
Gene ID 1674
Positive Control WB: mouse heart tissue lysate; IHC: human heart tissue section
Application & Usage IHC: 1:1000 -1:4000 dilution; WB: 1:1000 - 1:2000 dilution
Alias Symbol DES
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-Desmin Rabbit Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DES
Function Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z- line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).
Cellular Location Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm Cell membrane, sarcolemma. Nucleus {ECO:0000250|UniProtKB:P31001}. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190). Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:26724190}
Research Areas
Citations (0)
citation

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Background

Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

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Discontinued
Cat# ABV11825-50
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