Anti-Cytokeratin 5, Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
---|---|
Primary Accession | P13647 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Isotype | Rabbit IgG |
Calculated MW | 62378 Da |
Gene ID | 3852 |
---|---|
Positive Control | WB: A431 cell lysate; IHC: human tonsil tissue |
Application & Usage | IHC: 1:100 dilution; WB: 1:1000 dilution |
Alias Symbol | KRT5 |
Other Names | Keratin type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, KRT8, CYK8, KO, CK8, K2C8, CARD2 |
Appearance | Colorless liquid |
Formulation | In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Anti-Cytokeratin 5, Rabbit Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KRT5 |
---|---|
Function | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Keratin 8 (KRT8) belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.
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