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Anti-Cytokeratin 5, Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibody

     
  • IHC - Anti-Cytokeratin 5, Rabbit Monoclonal Antibody ABV11830-50
    Immunohistochemical staining of FFPE human tonsil tissue sections, using anti-Cytokeratin 5 rabbit monoclonal antibody.
    detail
  • IHC - Anti-Cytokeratin 5, Rabbit Monoclonal Antibody ABV11830-50
    Immunohistochemical staining of FFPE human tonsil tissue sections, using anti-Cytokeratin 5 rabbit monoclonal antibody.
    detail
  • WB - Anti-Cytokeratin 5, Rabbit Monoclonal Antibody ABV11830-50
    Western blot of A431 cell lysates using anti-Cytokeratin 5 rabbit monoclonal antibody showed a band of Cytokeratin 5 expressed in A431 cells.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P13647
Reactivity Human
Host Rabbit
Clonality Monoclonal
Isotype Rabbit IgG
Calculated MW 62378 Da
Additional Information
Gene ID 3852
Positive Control WB: A431 cell lysate; IHC: human tonsil tissue
Application & Usage IHC: 1:100 dilution; WB: 1:1000 dilution
Alias Symbol KRT5
Other Names Keratin type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, KRT8, CYK8, KO, CK8, K2C8, CARD2
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-Cytokeratin 5, Rabbit Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT5
Function Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity).
Cellular Location Cytoplasm.
Tissue Location Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245).
Research Areas
Citations (0)
citation

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Background

Keratin 8 (KRT8) belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.

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Discontinued
Cat# ABV11830-50
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