|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||134742 Da|
|Positive Control||WB: HeLa, HEK293 and PC12 cell lysates; IHC: human brain sections|
|Application & Usage||WB; 1:500 – 1:2000, IH; 1:50 – 1:200|
|Other Names||NPHN; Nephrin; Renal glomerulus-specific cell adhesion receptor|
|Formulation||In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide|
|Reconstitution & Storage||-20 °C|
|Precautions||Nephrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane|
|Tissue Location||Specifically expressed in podocytes of kidney glomeruli|
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Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion
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