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Phospho-MYPT1 (Thr696) Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | O14974 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 115281 Da |
| Gene ID | 4659 |
|---|---|
| Positive Control | WB: HEK293 cell lysates; IHC: human breast cancer tissue; IFC: HEK293 cells |
| Application & Usage | WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100 |
| Alias Symbol | PPP1R12A |
| Other Names | MBS, MYPT1, Protein phosphatase 1 regulatory subunit 12A, Myosin phosphatase-targeting subunit 1, Myosin phosphatase target subunit 1, Protein phosphatase myosin-binding subunit, Myosin phosphatase |
| Appearance | Colorless liquid |
| Formulation | In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Phospho-MYPT1 (Thr696) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPP1R12A (HGNC:7618) |
|---|---|
| Function | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, stress fiber. Note=Also along actomyosin filaments |
| Tissue Location | Expressed in striated muscles, specifically in type 2a fibers (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
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