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Anti-TEAD2 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - Anti-TEAD2 Antibody ABV11861-100
    Immunohistochemical analysis of TEAD2 staining in H.breast cancer formalin fixed paraffin embedded tissue section.
    detail
  • IF - Anti-TEAD2 Antibody ABV11861-100
    Immunofluorescent analysis of TEAD2 staining in HepG2 cells.
    detail
  • WB - Anti-TEAD2 Antibody ABV11861-100
    Western blot analysis of TEAD2 expression in HEK293(A); RAW264.7(B); H9C2(C)whole cell lysates.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, ICC
Primary Accession Q15562
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 49243 Da
Additional Information
Gene ID 8463
Positive Control WB: HEK293, RAW264.7, H9C2 cell lysate; IHC: human bresat cancer tissue; IF: HepG2 cells
Application & Usage WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100, ChIP 1:100 – 1:500
Alias Symbol TEAD2
Other Names TEF4, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-TEAD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TEAD2
Synonyms TEF4
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Cellular Location Nucleus.
Research Areas
Citations (0)
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Background

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

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Discontinued
Cat# ABV11861-100
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