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Anti-ICK Antibody

Rabbit Polyclonal Antibody

     
  • IHC - Anti-ICK Antibody ABV11866-100
    Immunohistochemical analysis of ICK staining in H.brain formalin fixed paraffin embedded tissue section.
  • IF - Anti-ICK Antibody ABV11866-100
    Immunofluorescent analysis of ICK staining in HEK293T cells.
  • WB - Anti-ICK Antibody ABV11866-100
    Western blot analysis of ICK expression in Hela(A); HEK293T(B) whole cell lysates.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, ICC
Primary Accession Q9UPZ9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 71427 Da
Additional Information
Gene ID 22858
Positive Control WB: HeLa, HEL293 cell lysates; IHC: human brain tissue; IFC: HEK293T cells
Application & Usage WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100
Alias Symbol ICK
Other Names KIAA0936, Serine/threonine-protein kinase ICK, Intestinal cell kinase, hICK, Laryngeal cancer kinase 2, LCK2, MAK-related kinase, MRK
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-ICK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICK
Synonyms KIAA0936
Function Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).
Cellular Location Nucleus. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62726}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9JKV2} Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360)
Tissue Location Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen Also expressed in many cancer cell lines
Research Areas
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Background

Required for ciliogenesis. Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.

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$ 295.00
Cat# ABV11866-100
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