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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-XRCC3 Antibody   

Anti-XRCC3 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - Anti-XRCC3 Antibody ABV11870-100
    Immunohistochemical analysis of XRCC3 staining in H.tonsil formalin fixed paraffin embedded tissue section.
  • IF - Anti-XRCC3 Antibody ABV11870-100
    Immunofluorescent analysis of XRCC3 staining in Hela cells.
  • WB - Anti-XRCC3 Antibody ABV11870-100
    Western blot analysis of XRCC3 expression in Hela(A); M.kidney(B); R.kidney(C) whole cell lysates.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, ICC
Primary Accession O43542
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 37850 Da
Additional Information
Gene ID 7517
Positive Control WB: HeLa, mouse kidney, rat kidney lysates; IHC: human tonsil tissue; IFc: HeLa cell
Application & Usage WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100
Alias Symbol XRCC3
Other Names DNA repair protein XRCC3; X-ray repair cross-complementing protein 3
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-XRCC3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XRCC3
Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair
Research Areas
Citations (0)

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Background

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

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$ 295.00
Cat# ABV11870-100
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