Anti-ZNT2 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IH |
---|---|
Primary Accession | Q9BRI3 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Isotype | Rabbit IgG |
Calculated MW | 40564 Da |
Gene ID | 7780 |
---|---|
Positive Control | WB: HeLa, RAW264.7, PC12 cell lystae; IHC: human lung cancer |
Application & Usage | WB; 1:500 – 1:2000, IHC; 1:50 – 1:200 |
Other Names | ZNT2, Zinc transporter 2, ZnT-2, Solute carrier family 30 member 2 |
Target/Specificity | SLC30A2 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Handling | The antibody solution should be gently mixed before use |
Reconstitution & Storage | -20°C |
Background Descriptions | |
Precautions | Anti-ZNT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC30A2 (HGNC:11013) |
---|---|
Function | [Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:21289295, PubMed:25808614, PubMed:25657003, PubMed:30893306, PubMed:17065149, PubMed:22733820). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614). |
Cellular Location | [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Zymogen granule membrane {ECO:0000250|UniProtKB:Q2HJ10}; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Note=Localization to lysosomes is induced by TNF-alpha |
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