|Reactivity||Human, Mouse, Rat|
|Calculated MW||50141 Da|
|Positive Control||WB: H9C2 PMA-treated (A) whole cell lysates|
|Application & Usage||WB; 1:500 – 1:2000|
|Other Names||AcK146, EEF1A1, EEF1A, EF1A, LENG7, Elongation factor 1-alpha 1, EF-1-alpha-1, Elongation factor Tu, EF-Tu; Eukaryotic elongation factor 1 A-1, eEF1A-1, Leukocyte receptor cluster member 7, EEF1A2, EEF1AL, STN, Elongation factor 1-alpha 2, EF-1-alpha-2, Eukaryotic elongation factor 1 A-2, eEF1A-2, Statin-S1, EEF1A1P5, EEF1AL3, Putative elongation factor 1-alpha-like 3, EF-1-alpha-like 3, Eukaryotic elongation factor 1 A-like 3, eEF1A-like 3, Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5|
|Handling||The antibody solution should be gently mixed before use|
|Reconstitution & Storage||-20°C|
|Precautions||Anti-EEF1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||EEF1A, EF1A, LENG7|
|Function||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, nucleolus. Cell membrane. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340) Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580) Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934).|
|Tissue Location||Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle|
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