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Phospho Alpha-synuclein (Tyr125) Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P37840 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Calculated MW | 14460 Da |
| Gene ID | 6622 |
|---|---|
| Positive Control | WB; HeLa, mouse brain, rat brain lysate, IHC; human brain tissue |
| Application & Usage | WB; 1:500 – 1:2000, IHC; 1:50 – 1:200 |
| Other Names | NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Target/Specificity | SNCA |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Handling | The antibody solution should be gently mixed before use |
| Reconstitution & Storage | -20°C |
| Background Descriptions | |
| Precautions | Phospho Alpha-synuclein (Tyr125) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNCA |
|---|---|
| Synonyms | NACP, PARK1 |
| Function | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). |
| Cellular Location | Cytoplasm. Membrane. Nucleus. Synapse Secreted. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:O55042, ECO:0000269|PubMed:15282274} |
| Tissue Location | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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