|Reactivity||Human, Mouse, Rat|
|Calculated MW||42794 Da|
|Positive Control||WB: MCF7, mouse heart, rat heart lysate|
|Application & Usage||WB; 1:500 – 1:2000|
|Other Names||Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial; Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma|
|Handling||The antibody solution should be gently mixed before use|
|Reconstitution & Storage||-20°C|
|Precautions||Anti-IDH3 gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.|
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