|Calculated MW||237136 Da|
|Positive Control||WB: A549, HepG2, PC3, rat testis lysates; IF/IC: HepG2 cells|
|Application & Usage||WB; 1:500 – 1:2000, IF/IC; 1:50 – 1:100|
|Other Names||KIAA0981; PIP5K3; 1-phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase|
|Handling||The antibody solution should be gently mixed before use|
|Reconstitution & Storage||-20°C|
|Precautions||Anti-PIP5K Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.|
|Cellular Location||Endosome membrane Note=Mainly associated with membranes of the late endocytic pathway|
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