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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Phospho-ASK 1 (Ser83) Antibody   

Phospho-ASK 1 (Ser83) Antibody

     
  • WB - Phospho-ASK 1 (Ser83) Antibody ABV11982-100
    WB (WB) analysis of 293 cells using Phospho-ASK 1 (S83) Polyclonal Antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q99683
Reactivity Human
Host Rabbit
Isotype Rabbit IgG
Calculated MW 154537 Da
Additional Information
Gene ID 4217
Positive Control WB: 293 cell lysate
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; E 1:20000;
Other Names Apoptosis signal-regulating kinase 1, Mitogen-activated protein kinase kinase kinase 5, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
Target/Specificity MAP3K5
Antibody Form Liquid
Appearance Colorless liquid
Handling The antibody solution should be gently mixed before use
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsPhospho-ASK 1 (Ser83) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K5
Synonyms ASK1, MAPKKK5, MEKK5
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Cellular Location Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region
Tissue Location Abundantly expressed in heart and pancreas.
Research Areas
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$ 285.00
Cat# ABV11982-100
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