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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Phospho-Caveolin-1 (Tyr14) Antibody   

Phospho-Caveolin-1 (Tyr14) Antibody

     
  • WB - Phospho-Caveolin-1 (Tyr14) Antibody ABV11985-100
    Fig A. WB (WB) analysis of HeLa cells using Fhospho-Caveolin-1 (Y14) Polyclonal Antibody Fig B. WB (WB) analysis of A549 cells using Phospho-Caveolin-1 (Y14) Polyclonal Antibody
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q03135
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype Rabbit IgG
Calculated MW 20472 Da
Additional Information
Gene ID 857
Positive Control WB: HeLa cell, A549 cell lysate
Application & Usage WB 1:500-1:2000; E 1:5000
Other Names Caveolin-1, CAV1, CAV
Target/Specificity CAV1
Antibody Form Liquid
Appearance Colorless liquid
Handling The antibody solution should be gently mixed before use
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsPhospho-Caveolin-1 (Tyr14) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAV1
Synonyms CAV
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
Cellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane Membrane protein of caveolae
Tissue Location Expressed in muscle and lung, less so in liver, brain and kidney
Research Areas
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$ 285.00
Cat# ABV11985-100
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