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Phospho-c-Myc (Thr58) Antibody

     
  • WB - Phospho-c-Myc (Thr58) Antibody ABV11997-100
    Fig. A. WB analysis of NIH/3T3 cells using Phospho-c-Myc (T58) Polyclonal Antibody Fig. B. WB (WB) analysis of 293 cells using Phospho-c-Myc (T58) Polyclonal Antibody
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E, IP
Primary Accession P01106
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype Rabbit IgG
Calculated MW 50565 Da
Additional Information
Gene ID 4609
Positive Control WB: 3T3 and 293 cell lysate
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-1:500; E 1:10000
Other Names Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
Target/Specificity MYC
Antibody Form Liquid
Appearance Colorless liquid
Handling The antibody solution should be gently mixed before use
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsPhospho-c-Myc (Thr58) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYC
Synonyms BHLHE39
Function Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808).
Cellular Location Nucleus, nucleoplasm. Nucleus, nucleolus
Research Areas
Citations (0)
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Discontinued
Cat# ABV11997-100
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