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Anti-S1P1 Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E, IP |
|---|---|
| Primary Accession | P21453 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 2B9 |
| Calculated MW | 42811 Da |
| Gene ID | 1901 |
|---|---|
| Application & Usage | WB: HUVEC cells, IP: CHO-S1P1-GFP cell membranes, IF: HUVEC cells |
| Other Names | S1P Receptor 1, S1PR1, Sphingosine 1-Phosphate Receptor 1, Endothelial differentiation GProtein Coupled Receptor 1, EDG-1. |
| Target/Specificity | S1PR1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | Phosphate Buffer 10mM - NaCl 0.15M - pH 7,4 |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-S1P1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | S1PR1 |
|---|---|
| Synonyms | CHEDG1, EDG1 |
| Function | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization |
| Tissue Location | Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Sphingosine 1-Phosphate Receptor 1 (S1P1) is a multi-pass cell membrane protein that belongs to the Gprotein coupled receptor superfamily (GPCR). S1P1 is a receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Clinical significance of S1P1 encompasses various diseases including cancer and multiple sclerosis. S1P1 seems to be coupled to the G(i/o) subclass of heteromeric G proteins
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