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Anti-KDM5C / Jarid1C / SMCX Antibody
Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | P41229 |
| Reactivity | Human |
| Host | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 2E4-E1-G8 |
| Calculated MW | 175720 Da |
| Gene ID | 8242 |
|---|---|
| Application & Usage | WB: HeLa, 293, T$7D, MCF7 cell lysates; IF: HeLa cells |
| Other Names | MRXJ, SMCX, MRXSJ, XE169, MRXSCJ, JARID1C, DXS1272E, Lysine-specific demethylase 5C, Jumonji/ARID domain-containing protein 1C |
| Target/Specificity | KDM5C |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-KDM5C / Jarid1C / SMCX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM5C (HGNC:11114) |
|---|---|
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742} |
| Tissue Location | Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2
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