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Anti-PPP4C Antibody (2F11-D10-G4)

Mouse Monoclonal Antibody

     
  • WB - Anti-PPP4C Antibody (2F11-D10-G4) ABV12074-100
    Western blot detection of Protein Phosphatase 4C in Hefa and Jurkat cell lysates using Protein Phosphatase 4C Antibody
    detail
  • IHC - Anti-PPP4C Antibody (2F11-D10-G4) ABV12074-100
    Immunocytochemistry of HeLa cells using anti-Protein Phosphatase 4C Antibody
    detail
  • IF - Anti-PPP4C Antibody (2F11-D10-G4) ABV12074-100
    IHC of paraffin-embedded human breast cancer using anti-Protein Phosphatase 4C Antibody
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession P60510
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG2a
Clone Names 2F11-D10-G4
Calculated MW 35080 Da
Additional Information
Gene ID 5531
Positive Control WB: Hela and Jurkat cell lysates; IF: HeLa cells; IHC: human breast cancer tissue
Application & Usage WB; 1:200, IF; 1:200
Other Names Pp4, Protein phosphatase X, PP-X, PPP4C, PPP4, PPX
Target/Specificity Serine/threonine-protein phosphatase 4 catalytic subunit
Antibody Form Liquid
Appearance Colorless liquid
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-PPP4C Antibody (2F11-D10-G4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP4C
Synonyms PPP4, PPX
Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)
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Background

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.

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Discontinued
Cat# ABV12074-100
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