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Anti-AFP Antibody (1D9H5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P02771 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1, κ |
| Clone Names | 1D9H5 |
| Calculated MW | 68678 Da |
| Gene ID | 174 |
|---|---|
| Positive Control | ELISA |
| Application & Usage | ELISA Capture: 1-10 µg/ml, ELISA Detection: 0.05-0.2 µg/ml |
| Other Names | Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP, AFP, Alpha-fetoprotein |
| Target/Specificity | Alpha-Feto Protein |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-AFP Antibody (1D9H5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFP |
|---|---|
| Synonyms | HPAFP |
| Function | Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. |
| Cellular Location | Secreted. |
| Tissue Location | Plasma. Synthesized by the fetal liver and yolk sac |
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Provided below are standard protocols that you may find useful for product applications.
Background
AFP (Alpha-Feto Protein) is a glycoprotein with molecular weight of approximately 70 kDa. It is a major protein in developing fetus and decreases to lower level after birth. In healthy adults, less than 20 ng/ml of AFP is found in the serum. Serum AFP elevates when hepatocellular carcinoma or testicular germ cell tumors occurs. Therefore, it is a useful marker in diagnosing hepatocellular carcinoma and germ cell tumors. In addition, for pregnant women, the AFP concentration is 10-150 ng/ml in the blood. High levels of AFP can indicate a neural tube defect of the fetus, such us spina bifida. AFP Antibody is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with AFP protein purified from human hepatocellular carcinoma
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