|Isotype||Mouse IgG1, κ|
|Calculated MW||76795 Da|
|Application & Usage||ELISA Capture: 1-10 µg/ml, ELISA Detection: 0.05-0.2 µg/ml|
|Other Names||CEA, Meconium antigen 100, CD_antigen: CD66e, Carcinoembryonic antigen-related cell adhesion molecule 5|
|Reconstitution & Storage||-20 °C|
|Precautions||Anti-CEA Antibody (3C5C10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).|
|Cellular Location||Cell membrane; Lipid- anchor, GPI-anchor. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface|
|Tissue Location||Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.|
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Carcinoembryonic antigen (CEA) is a complex glycoprotein of molecular weight 200 kDa. In healthy adults, less than 5 ng/ml of CEA is found in the serum. Elevation of CEA antigen is found in the blood of patients with cancer of the lung, liver, pancreas, breast, cervix, prostate and so on. CEA measurement is mainly used as a tumor marker to identify recurrences after surgical resection, or localize cancer spread though dosage of biological fluids. The CEA blood test is not reliable for diagnosing cancer. CEA levels may also be raised in some conditions like ulcerative colitis, pancreatitis and cirrhosis. CEA Antibody is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with native human CEA protein
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