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Anti-Proinsulin Antibody (1A3D8)

Mouse Monoclonal Antibody

     
  • E - Anti-Proinsulin Antibody (1A3D8) ABV12093-500
    Cross-reactivity of Proinsulin monoclonal antibodies by Indirect ELISA
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession P01308
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1, κ
Clone Names 1A3D8
Calculated MW 11981 Da
Additional Information
Gene ID 3630
Positive Control ELISA
Target/Specificity Proinsulin
Antibody Form Liquid
Appearance Colorless liquid
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-Proinsulin Antibody (1A3D8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name INS
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. It is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where it is packaged into secretory vesicles, and where it is processed by a series of proteases to form mature insulin. Mature insulin has 35 fewer amino acids; 4 are removed altogether, and the remaining 31 forms C‐peptide. The C‐peptide is abstracted from the center of the proinsulin sequence; the two other ends (the B chain and A chain) remain connected by disulfide bonds. Proinsulin Antibody is produced from the hybridoma resulting from fusion of SP2/‐Ag14 myeloma and B‐lymphocytes obtained from mouse immunized with human recombinant proinsulin.

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$ 265.00
Cat# ABV12093-500
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