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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Lactoferrin Antibody (10D04)   

Anti-Lactoferrin Antibody (10D04)

Mouse Monoclonal Antibody

     
  • E - Anti-Lactoferrin Antibody (10D04) ABV12107-500
    The antibodies were evaluated for their ability to work as matched pairs in a mono-mono sandwich ELISA format. Biotin conjugates of both antibodies were prepared for use as tracers. The antibodies demonstrated the ability to work in both capture/tracer configurations
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession P02788
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1, κ
Clone Names 10D04
Calculated MW 78182 Da
Additional Information
Gene ID 4057
Positive Control ELISA
Other Names Growth-inhibiting protein 12, Talalactoferrin, Lactotransferrin
Target/Specificity Lactoferrin
Antibody Form Liquid
Appearance Colorless liquid
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-Lactoferrin Antibody (10D04) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTF
Synonyms GIG12, LF
Function Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.
Cellular Location Isoform 1: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils
Tissue Location High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels Detected in peripheral blood neutrophils (at protein level) Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.
Research Areas
Citations (0)

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Background

Lactoferrin is a glycoprotein present in exocrine secretions and in the secondary granules of polymorphonuclear neutrophils. It is the iron binding protein in milk. Lactoferrin is known to regulate intestinal iron absorption, and to participate in the defense against bacteria. Lactoferrin is part of the transferrin family of proteins, an iron binding glycoprotein involved in host defense against infection and is a modulator of inflammatory reactions.

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$ 395.00
Cat# ABV12107-500
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