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Anti-SHH Antibody

Rabbit Polyclonal Antibody

     
  • WB - Anti-SHH Antibody ABV12112-30
    Western blot analysis of SHH antibody in: Lane 1: SHH human recombinant 2 ng Lane 2: SHH human recombinant 10 ng Lane 3: SHH human recombinant 50 ng
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q15465
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 49607 Da
Additional Information
Gene ID 6469
Positive Control Western blot
Application & Usage Western blot: 1-4 µg/ml
Other Names Sonic hedgehog protein, HHG-1, SHH
Target/Specificity SHH
Antibody Form Liquid
Appearance Colorless liquid
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsAnti-SHH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHH
Function Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).
Cellular Location Sonic hedgehog protein C-product: Secreted, extracellular space {ECO:0000250|UniProtKB:Q62226}. Note=The C- terminal peptide diffuses from the cell {ECO:0000250|UniProtKB:Q62226}
Tissue Location Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues
Citations (0)

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Background

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO.

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$ 89.00
$ 265.00
Cat# ABV12112-30
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