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TIP5 polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • CHIP - TIP5 polyclonal antibody ADN10052
    ChIP results obtained with the antibody directed against TIP5 
  • WB - TIP5 polyclonal antibody ADN10052
    Western blot analysis using the antibody directed against TIP5 
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9UIF9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 211198 Da
Additional Information
Gene ID 11176
Other Names Bromodomain adjacent to zinc finger domain protein 2A, Transcription termination factor I-interacting protein 5, TTF-I-interacting protein 5, Tip5, hWALp3, BAZ2A, KIAA0314, TIP5
Target/Specificity TIP5
PrecautionsTIP5 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAZ2A
Function Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity).
Cellular Location Nucleus, nucleolus. Note=Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus.
Tissue Location Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas
Citations (0)

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Background

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity).

References

Jones M.H.,et al.Genomics 63:40-45(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

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$ 290.00
Cat# ADN10052
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