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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CIITA polyclonal antibody   

CIITA polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • CHIP - CIITA polyclonal antibody ADN10097
    ChIP results obtained with the antibody directed against CIITA
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Primary Accession P33076
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 123514 Da
Additional Information
Gene ID 4261
Other Names MHC class II transactivator, CIITA, 2.3.1.-, 2.7.11.1, CIITA, MHC2TA
Target/Specificity CIITA
PrecautionsCIITA polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIITA
Function Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).
Cellular Location Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML
Research Areas
Citations (0)

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Background

Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).

References

Steimle V.,et al.Cell 75:135-146(1993).
Riley J.L.,et al.Immunity 2:533-543(1995).
Quinn G.,et al.Eur. J. Immunogenet. 30:259-270(2003).
Day N.E.,et al.Leuk. Res. 27:1027-1038(2003).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

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$ 290.00
Cat# ADN10097
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