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MBD1 polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • CHIP - MBD1 polyclonal antibody ADN10105
    ChIP results obtained with the antibody directed against MBD1
  • E - MBD1 polyclonal antibody ADN10105
    Determination of the antibody titer
  • WB - MBD1 polyclonal antibody ADN10105
    Western blot analysis using the antibody directed against MBD1
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UIS9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 66607 Da
Additional Information
Gene ID 4152
Other Names Methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, MBD1, CXXC3, PCM1
Target/Specificity MBD1
PrecautionsMBD1 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD1
Function Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Cellular Location Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Note=Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes.
Tissue Location Widely expressed.
Citations (0)

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Background

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

References

Cross S.H.,et al.Nat. Genet. 16:256-259(1997).
Hendrich B.,et al.Mamm. Genome 10:906-912(1999).
Fujita N.,et al.Mol. Cell. Biol. 19:6415-6426(1999).
Andersen J.B.,et al.Eur. J. Biochem. 271:628-636(2004).
Laget S.M.,et al.Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.

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$ 290.00
Cat# ADN10105
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