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PPARG polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • CHIP - PPARG polyclonal antibody ADN10116
    ChIP results obtained with the antibody directed against PPARG 
  • E - PPARG polyclonal antibody ADN10116
    Determination of the titer 
  • WB - PPARG polyclonal antibody ADN10116
    Western blot analysis using the antibody directed against PPARG 
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P37231
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 57620 Da
Additional Information
Gene ID 5468
Other Names Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3
Target/Specificity PPARG
PrecautionsPPARG polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPARG
Function Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner NOCT enhances its nuclear translocation
Tissue Location Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
Research Areas
Citations (0)

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Background

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

References

Mukherjee R.,et al.J. Biol. Chem. 272:8071-8076(1997).
Elbrecht A.,et al.Biochem. Biophys. Res. Commun. 224:431-437(1996).
Yanase T.,et al.Biochem. Biophys. Res. Commun. 233:320-324(1997).
Greene M.E.,et al.Gene Expr. 4:281-299(1995).
Greene M.E.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.

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$ 290.00
Cat# ADN10116
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