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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   MeCP2 polyclonal antibody   

MeCP2 polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • WB - MeCP2 polyclonal antibody ADN10133
    Western blot analysis using the antibody directed against MeCP2
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P51608
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 52441 Da
Additional Information
Gene ID 4204
Other Names Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Target/Specificity MeCP2
PrecautionsMeCP2 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MECP2
Function Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Cellular Location Nucleus. Note=Colocalized with methyl-CpG in the genome
Tissue Location Present in all adult somatic tissues tested.
Research Areas
Citations (0)

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Background

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).

References

Kudo S.,et al.Mol. Cell. Biol. 18:5492-5499(1998).
Vilain A.,et al.Cytogenet. Cell Genet. 74:293-294(1996).
Coy J.F.,et al.Hum. Mol. Genet. 8:1253-1262(1999).
Reichwald K.,et al.Mamm. Genome 11:182-190(2000).
Mnatzakanian G.N.,et al.Nat. Genet. 36:339-341(2004).

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$ 290.00
Cat# ADN10133
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