|Application ||WB, E|
|Calculated MW||66051 Da|
|Other Names||Methyl-CpG-binding domain protein 4, 3.2.2.-, Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase, MBD4, MED1|
|Precautions||MBD4 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.|
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Provided below are standard protocols that you may find useful for product applications.
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
Hendrich B.,et al.Mol. Cell. Biol. 18:6538-6547(1998).
Hendrich B.,et al.Mamm. Genome 10:906-912(1999).
Bellacosa A.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:3969-3974(1999).
Owen R.M.,et al.Oncol. Rep. 17:111-116(2007).
Guo J.H.,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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