|Application ||WB, E|
|Calculated MW||111835 Da|
|Other Names||Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1|
|Precautions||Hira polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.|
|Cellular Location||Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence|
|Tissue Location||Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Lamour V.,et al.Hum. Mol. Genet. 4:791-799(1995).
Lorain S.,et al.Genome Res. 6:43-50(1996).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Halford S.,et al.Hum. Mol. Genet. 2:2099-2107(1993).
Wilming L.G.,et al.Hum. Mol. Genet. 6:247-258(1997).
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