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Hira polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - Hira polyclonal antibody ADN10170
    Determination of the titer 
  • WB - Hira polyclonal antibody ADN10170
    Western blot analysis using the antibody directed against Hira (1) 
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P54198
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 111835 Da
Additional Information
Gene ID 7290
Other Names Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1
Target/Specificity Hira
PrecautionsHira polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIRA
Function Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Cellular Location Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence
Tissue Location Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.
Research Areas
Citations (0)

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Background

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

References

Lamour V.,et al.Hum. Mol. Genet. 4:791-799(1995).
Lorain S.,et al.Genome Res. 6:43-50(1996).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Halford S.,et al.Hum. Mol. Genet. 2:2099-2107(1993).
Wilming L.G.,et al.Hum. Mol. Genet. 6:247-258(1997).

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$ 195.00
Cat# ADN10170
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