|Application ||WB, E|
|Calculated MW||111835 Da|
|Other Names||Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1|
|Precautions||Hira polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.|
|Cellular Location||Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence|
|Tissue Location||Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Lamour V.,et al.Hum. Mol. Genet. 4:791-799(1995).
Lorain S.,et al.Genome Res. 6:43-50(1996).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Halford S.,et al.Hum. Mol. Genet. 2:2099-2107(1993).
Wilming L.G.,et al.Hum. Mol. Genet. 6:247-258(1997).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.