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Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UBB5 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43255 Da |
| Gene ID | 8932 |
|---|---|
| Other Names | Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2 |
| Target/Specificity | MBD2 |
| Precautions | MBD2 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBD2 |
|---|---|
| Function | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
| Cellular Location | Nucleus. Note=Nuclear, in discrete foci Detected at replication foci in late S phase |
| Tissue Location | Highly expressed in brain, heart, kidney, stomach, testis and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
References
Hendrich B.,et al.Mol. Cell. Biol. 18:6538-6547(1998).
Hendrich B.,et al.Mamm. Genome 10:906-912(1999).
Bhattacharya S.K.,et al.Nature 397:579-583(1999).
Ng H.-H.,et al.Nat. Genet. 23:58-61(1999).
Tatematsu K.,et al.Genes Cells 5:677-688(2000).
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