|Application ||WB, E|
|Calculated MW||593389 Da|
|Other Names||Histone-lysine N-methyltransferase 2D, Lysine N-methyltransferase 2D, 22.214.171.124, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2, KMT2D, ALR, MLL2, MLL4|
|Precautions||Mll4 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.|
|Tissue Location||Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver|
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Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
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Scherer S.E.,et al.Nature 440:346-351(2006).
Goo Y.-H.,et al.Mol. Cell. Biol. 23:140-149(2003).
Olsen J.V.,et al.Cell 127:635-648(2006).
Mo R.,et al.J. Biol. Chem. 281:15714-15720(2006).
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