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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   JMJD2c polyclonal antibody   

JMJD2c polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - JMJD2c polyclonal antibody ADN10175
    Determination of the titer
  • E - JMJD2c polyclonal antibody ADN10175
    Cross reactivity test using the antibody directed against H3K23ac
  • WB - JMJD2c polyclonal antibody ADN10175
    Western blot analysis using the antibody against H3K23ac
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H3R0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 119982 Da
Additional Information
Gene ID 23081
Other Names Lysine-specific demethylase 4C, 1.14.11.-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780
Target/Specificity JMJD2c
PrecautionsJMJD2c polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4C
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}
Tissue Location Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Research Areas
Citations (0)

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Background

Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

References

Yang Z.Q.,et al.Cancer Res. 60:4735-4739(2000).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Whetstine J.R.,et al.Cell 125:467-481(2006).

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$ 190.00
Cat# ADN10175
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