|Application ||WB, E|
|Calculated MW||51212 Da|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, 18.104.22.168, 51 kDa FK506-binding protein, 51 kDa FKBP, FKBP-51, 54 kDa progesterone receptor-associated immunophilin, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP-5, FKBP54, p54, HSP90-binding immunophilin, Rotamase, FKBP5, AIG6, FKBP51|
|Precautions||FKBP51 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Widely expressed, enriched in testis compared to other tissues|
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Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
Baughman G.,et al.Biochem. Biophys. Res. Commun. 232:437-443(1997).
Zhang J.S.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
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