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Setd1a polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - Setd1a polyclonal antibody ADN10185
    Determination of the titer
  • WB - Setd1a polyclonal antibody ADN10185
    Western blot analysis using the antibody directed against mouse Setd1a (1)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O15047
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 186034 Da
Additional Information
Gene ID 9739
Other Names Histone-lysine N-methyltransferase SETD1A, 2.1.1.43, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, hSET1A, Set1/Ash2 histone methyltransferase complex subunit SET1, SETD1A
Target/Specificity Setd1a
PrecautionsSetd1a polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD1A
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.
Cellular Location Nucleus speckle. Chromosome. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes
Citations (0)

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Background

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.

References

Nagase T.,et al.DNA Res. 4:141-150(1997).
Martin J.,et al.Nature 432:988-994(2004).
Wysocka J.,et al.Genes Dev. 17:896-911(2003).
Lee J.-H.,et al.J. Biol. Chem. 280:41725-41731(2005).
Olsen J.V.,et al.Cell 127:635-648(2006).

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$ 190.00
Cat# ADN10185
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