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Setd1b polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - Setd1b polyclonal antibody ADN10186
    Determination of the titer
  • WB - Setd1b polyclonal antibody ADN10186
    Western blot analysis using the antibody directed against JMJD2c
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UPS6
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 212803 Da
Additional Information
Gene ID 23067
Other Names Histone-lysine N-methyltransferase SETD1B, 2.1.1.43, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B
Target/Specificity Setd1b
PrecautionsSetd1b polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD1B
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
Cellular Location Nucleus speckle. Chromosome. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes
Citations (0)

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Background

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

References

Lee J.H.,et al.PLoS ONE 7:E42965-E42965(2012).
Scherer S.E.,et al.Nature 440:346-351(2006).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Lee J.-H.,et al.J. Biol. Chem. 282:13419-13428(2007).
Lee J.H.,et al.Mol. Cell. Biol. 28:609-618(2008).

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$ 190.00
Cat# ADN10186
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