Setd1b polyclonal antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, E |
---|---|
Primary Accession | Q9UPS6 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 212803 Da |
Gene ID | 23067 |
---|---|
Other Names | Histone-lysine N-methyltransferase SETD1B, 2.1.1.43, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B |
Target/Specificity | Setd1b |
Precautions | Setd1b polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SETD1B |
---|---|
Function | Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. |
Cellular Location | Nucleus speckle. Chromosome. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes |

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Provided below are standard protocols that you may find useful for product applications.
Background
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
References
Lee J.H.,et al.PLoS ONE 7:E42965-E42965(2012).
Scherer S.E.,et al.Nature 440:346-351(2006).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Lee J.-H.,et al.J. Biol. Chem. 282:13419-13428(2007).
Lee J.H.,et al.Mol. Cell. Biol. 28:609-618(2008).

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