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PAPD1 polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - PAPD1 polyclonal antibody ADN10195
    Determination of the titer
  • WB - PAPD1 polyclonal antibody ADN10195
    Western blot analysis using the antibody directed against PAPD1
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NVV4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 66172 Da
Additional Information
Gene ID 55149
Other Names Poly(A) RNA polymerase, mitochondrial, PAP, 2.7.7.19, PAP-associated domain-containing protein 1, Polynucleotide adenylyltransferase, Terminal uridylyltransferase 1, TUTase 1, mtPAP, MTPAP, PAPD1
Target/Specificity PAPD1
PrecautionsPAPD1 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTPAP
Function Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
Cellular Location Cytoplasm. Mitochondrion.
Tissue Location Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.
Citations (0)

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Background

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.

References

Tomecki R.,et al.Nucleic Acids Res. 32:6001-6014(2004).
Nagaike T.,et al.J. Biol. Chem. 280:19721-19727(2005).
Kemmer D.,et al.BMC Genomics 7:48-48(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 190.00
Cat# ADN10195
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