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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   EIF2C1/2 polyclonal antibody   

EIF2C1/2 polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - EIF2C1/2 polyclonal antibody ADN10199
    Determination of the titer
  • WB - EIF2C1/2 polyclonal antibody ADN10199
    Western blot analysis using the antibody directed against EIF2C1/2
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UL18
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 97214 Da
Additional Information
Gene ID 26523
Other Names Protein argonaute-1, Argonaute1, hAgo1, Argonaute RISC catalytic component 1, Eukaryotic translation initiation factor 2C 1, eIF-2C 1, eIF2C 1, Putative RNA-binding protein Q99, AGO1, EIF2C1
Target/Specificity EIF2C1/2
PrecautionsEIF2C1/2 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGO1
Function Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
Cellular Location Cytoplasm, P-body
Research Areas
Citations (0)

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Background

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

References

Koesters R.,et al.Genomics 61:210-218(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
Meister G.,et al.Mol. Cell 15:185-197(2004).
Meister G.,et al.Curr. Biol. 15:2149-2155(2005).
Janowski B.A.,et al.Nat. Struct. Mol. Biol. 13:787-792(2006).

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$ 190.00
Cat# ADN10199
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