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CBX2 polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - CBX2 polyclonal antibody ADN10217
    Determination of the antibody titer
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession Q14781
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 56081 Da
Additional Information
Gene ID 84733
Other Names Chromobox protein homolog 2, CBX2
Target/Specificity CBX2
PrecautionsCBX2 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX2
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
Cellular Location Nucleus.
Citations (0)

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Background

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.

References

Zody M.C.,et al.Nature 440:1045-1049(2006).
Gecz J.,et al.Genomics 26:130-133(1995).
Levine S.S.,et al.Mol. Cell. Biol. 22:6070-6078(2002).
Biason-Lauber A.,et al.Am. J. Hum. Genet. 84:658-663(2009).
Maertens G.N.,et al.PLoS ONE 4:E6380-E6380(2009).

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$ 190.00
Cat# ADN10217
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