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CDYL polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - CDYL polyclonal antibody ADN10221
    Determination of the antibody titer
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession Q9Y232
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 66482 Da
Additional Information
Gene ID 9425
Other Names Chromodomain Y-like protein, CDY-like, 2.3.1.48, CDYL, CDYL1
Target/Specificity CDYL
PrecautionsCDYL polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDYL
Function Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.
Cellular Location Nucleus
Tissue Location Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform.
Citations (0)

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Background

Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.

References

Lahn B.T.,et al.Nat. Genet. 21:429-433(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Lahn B.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002).

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$ 190.00
Cat# ADN10221
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