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JMJD2b polyclonal antibody

Purified Rabbit Polyclonal Antibody

     
  • E - JMJD2b polyclonal antibody ADN10251
    Determination of the antibody titer
  • WB - JMJD2b polyclonal antibody ADN10251
    Western blot analysis using the antibody directed against JMJD2b
  • IF - JMJD2b polyclonal antibody ADN10251
    Immunofluorescence using the antibody directed against JMJD2b
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O94953
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 121897 Da
Additional Information
Gene ID 23030
Other Names Lysine-specific demethylase 4B, 1.14.11.-, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B, KDM4B, JHDM3B, JMJD2B, KIAA0876
Target/Specificity JMJD2b
PrecautionsJMJD2b polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4B
Function Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537, ECO:0000269|PubMed:15927959}
Citations (0)

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Background

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.

References

Nagase T.,et al.DNA Res. 5:355-364(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 290.00
Cat# ADN10251
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