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Functional BAFF (human) Antibody, mAb (blocking) (Biotin)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IP |
|---|---|
| Reactivity | Human |
| Host | Purified From Concentrated Hybridoma Tissue Culture Supernatant. |
| Clonality | Monoclonal |
| Isotype | Rat IgG2a |
| Gene Source | Human |
| Application Note | ,Functional Application, Inhibition of human BAFF binding,IP(1:200) |
| Clone Names | 4.62 |
| Other Names | BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B |
|---|---|
| Target/Specificity | Recognizes human BAFF. |
| Format | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Reconstitution & Storage | Stable for at least 1 year after receipt when stored at -20°C. |
| Precautions | Functional BAFF (human) Antibody, mAb (blocking) (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
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