|Application ||FC, ICC, IP|
|Host||Purified From Concentrated Hybridoma Tissue Culture Supernatant.|
|Application Note||FC,Functional Application, Inhibition (blocks TRAIL-R1 mediated killing if applied in solution),ICC,IP,|
|Calculated MW||50089 Da|
|Other Names||TRAIL Receptor 1; DR4; APO2; TNFRSF10A; CD261|
|Target/Specificity||Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.|
|Format||Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.|
|Reconstitution & Storage||Stable for at least 1 year after receipt when stored at -20°C.|
|Precautions||Functional TRAIL-R1 (human) Antibody, mAb(preservative free) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||APO2, DR4, TRAILR1|
|Function||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells|
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TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa.
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