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Functional TRAIL-R2 (human) Antibody, mAb(preservative free)

     
  • IHC - Functional TRAIL-R2 (human) Antibody, mAb(preservative free) ADP0013
    Immunohistochemical staining of TRAIL-R2 using anti-TRAIL-R2 (human), mAb (HS201) in formalin-fixed and paraffin-embedded (FFPE) human liver tissue (15 µg/ml).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, FC, ICC, IP
Primary Accession O14763
Reactivity Human
Host Purified From Concentrated Hybridoma Tissue Culture Supernatant.
Clonality Monoclonal
Isotype Mouse IgG1
Gene Source Human
Application Note FC,Functional Application, Inhibition (blocks TRAIL-R2 mediated killing if applied in solution),ICC,IHC-P(15 µg/ml),IP,
Clone Names HS201
Calculated MW 47878 Da
Additional Information
Gene ID 8795
Other Names TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262
Target/Specificity Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
Format Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Reconstitution & Storage Stable for at least 1 year after receipt when stored at -20°C.
PrecautionsFunctional TRAIL-R2 (human) Antibody, mAb(preservative free) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF10B
Synonyms DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
Research Areas
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Background

TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa.

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$ 370.00
Cat# ADP0013
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