|Application ||WB, IHC-F, ICC, IP|
|Endotoxin||<0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza).|
|Application Note||Functional Application,Inhibition,ICC,IHC-F (1:150),IP(10 µg/ml),WB(5 µg/ml)|
|Calculated MW||13755 Da|
|Other Names||Lymphocyte Activation Gene-3; FDC Protein; CD223|
|Target/Specificity||Recognizes human LAG-3.|
|Format||Liquid. In PBS containing 0.02% sodium azide.|
|Reconstitution & Storage||Stable for at least 1 year after receipt when stored at -20°C.|
|Precautions||Functional LAG-3 (human) Antibody, mAb (blocking)(preservative free) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|
|Cellular Location||Mitochondrion membrane; Multi- pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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