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Functional LAG-3 (human) Antibody, mAb (blocking)(preservative free)

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-F, ICC, IP
Primary Accession P18630
Reactivity Human
Clonality Monoclonal
Isotype Mouse IgG1
Gene Source Human
Endotoxin <0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza).
Application Note Functional Application,Inhibition,ICC,IHC-F (1:150),IP(10 µg/ml),WB(5 µg/ml)
Clone Names 17B4
Calculated MW 13755 Da
Additional Information
Other Names Lymphocyte Activation Gene-3; FDC Protein; CD223
Target/Specificity Recognizes human LAG-3.
Format Liquid. In PBS containing 0.02% sodium azide.
Reconstitution & Storage Stable for at least 1 year after receipt when stored at -20°C.
PrecautionsFunctional LAG-3 (human) Antibody, mAb (blocking)(preservative free) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ND3
Synonyms NAD3
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Cellular Location Mitochondrion membrane; Multi- pass membrane protein
Research Areas
Citations (0)

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Background

Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

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$ 300.00
Cat# ADP0018
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